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The effect of high-intensity interval training combined with selenium nanoparticles on the levels of myocardial NF-kB and TNF-α proteins in diabetic rats
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Reza Babaei Goshlondani   , Khalid Mohamadzadeh Salamat *  , Zaher Etemad , Payam Saidie |
| 1 Department of Exercise Physiology, Sa.C, Islamic Azad University, Sanandaj, Iran |
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Abstract: (6 Views) |
Background: Diabetes is a metabolic disorder that results in tissue hyperglycemia leading to tissue damage such as the myocardium. It seems that exercise and antioxidant agents play an important role in improving the myocardial cell apoptosis pathway in diabetic patients through inflammatory mechanisms, but the simultaneous effects of these two interventions are not clearly defined. The aim of the present study was to investigate the effect of high-intensity interval training (HIIT) combined with selenium nanoparticles on the levels of tumor necrosis factor alpha (TNF-α) and nuclear factor kappa (NF-κB) in the myocardium of diabetic rats.
Methods: Thirty-one 8-week-old male Wistar rats (weighing 250 ± 50 g) were randomly divided into 5 groups: diabetic control (DC), diabetic control solvent (CDS), diabetic exercise (DT), diabetic selenium (DS), and diabetic exercise + selenium (DST). Rats were made diabetic by intraperitoneal injection of 65 mg/kg streptozotocin (STZ). Selenium nanoparticles (0.1 mg/kg) were administered to the rats by gavage every other day. Rats in the training group performed an intense interval training program (80 to 95% VO2max) for 8 weeks, 5 days a week. Two-way ANOVA was used to analyze the levels of TNF-α and NF-κB in the myocardial tissue of rats, with a significance level of α = 0.05.
Results: The results showed that NF-ĸB was significantly different between the diabetic control and solvent groups with the exercise, selenium, and exercise + selenium groups (p = 0.001). Also, NF-ĸB and TNF-α showed the lowest values in the exercise + selenium group. However, no significant difference was observed between the exercise, selenium, and exercise + selenium groups (p > 0.05).
Conclusion: The results showed that all three interventions of HIIT training, selenium nanoparticle consumption, and training + selenium had a significant effect on inflammatory factors. However, although the simultaneous use of selenium nanoparticle during HIIT training caused a greater reduction in systemic inflammation, there was no significant difference compared to any of the training interventions and selenium nanoparticle consumption alone.
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| Keywords: Diabetes, Exercise, Inflammation, Selenium |
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Full-Text [PDF 1158 kb]
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Type of Study: Original Research |
Subject:
Cardiovascular System
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