[Home ] [Archive]   [ فارسی ]  
Main Menu
Journal Information::
Archive ::
For Authors::
For Reviewers::
Ethical Code::
Contact us::
Peer Review Process::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 8 - ::
Ir J Physiol Pharmacol 2025, 8 - : 11-22 Back to browse issues page
Intraperitoneal fluoxetine impact on local field potential power in insular and prefrontal cortex in chronic mild stress animal models
Samira Rshtiani , Mohamad Rostampour , Behrooz Khakpour-Taleghani , Kambiz Rohampour *
1. Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (115 Views)
Background and Aim: One of the hypotheses of the pathophysiology of depression is the occurrence of functional alterations in the neural networks, including the default mode network and the salient network. This study aims to investigate the electrophysiological changes of the medial prefrontal cortex (mPFC) and the insula region of these neural networks in an animal model of depression.
Methods: Twenty-eight male rats were divided into 4 control groups; chronic mild stress model (CMS), fluoxetine treated model (CMS + FLX), and fluoxetine recipient (FLX). Electrodes were placed in the mPFC and insula regions. Then, model rats were exposed to stressors every day for three weeks. The FLX group received one intraperitoneal injection of fluoxetine daily for two weeks. Finally, rats were evaluated with forced swimming, open field, and sucrose preference tests. Then the field potentials of the mentioned areas were recorded.
Results: CMS rats had a lower tendency to consume sucrose (p ≤ 0.001). The CMS group had longer immobility time compared to healthy and FLX-treated mice (p ≤ 0.05). There was no significant difference in the field potentials in the stress condition or under auditory stress. In both insula and mPFC regions, theta band power in the CMS group was significantly lower than the control and CMS + FLX group (p ≤ 0.05).
Conclusion: Chronic mild stress was able to reduce the theta frequency band in the insula and mPFC regions, and fluoxetine reversed these changes. This study confirms the occurrence of plastic changes in brain neural networks during depression.

Keywords: Chronic mild stress, Depression, Insula, Field potentials, Prefrontal cortex
Full-Text [PDF 1150 kb]   (41 Downloads)    
Type of Study: Original Research | Subject: Neuroscience
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rshtiani S, Rostampour M, Khakpour-Taleghani B, Rohampour K. Intraperitoneal fluoxetine impact on local field potential power in insular and prefrontal cortex in chronic mild stress animal models. Ir J Physiol Pharmacol 2025; 8 :11-22
URL: http://ijpp.phypha.ir/article-1-696-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 8 - Back to browse issues page
مجله فیزیولوژی و فارماکولوژی ایران Iranian Journal of Physiology and Pharmacology
Persian site map - English site map - Created in 0.05 seconds with 36 queries by YEKTAWEB 4657