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Effect of cell phone electromagnetic waves on spatial memory, anxiety and hippocampal apoptosis in male PTSD modeled wistar rats
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Maryam Alimohammadi   , Kataneh Abrari *  , Afsaneh Goudarzi |
| Department of Animal Sciences, Faculty of Biological Sciences, Kharazmi University, Karaj, Iran |
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Abstract: (335 Views) |
Background and Aim: Nowadays, humans are immersed in a sea of electromagnetic waves of natural or artificial origin and at the same time lead a stressful life. The aim of this study is to investigate the simultaneous effect of mobile phone electromagnetic waves and post-traumatic stress disorder (PTSD) on spatial memory.
Methods: For this study, 40 rats were divided into 4 groups: naive group, PTSD group, electromagnetic wave group, and electromagnetic wave + PTSD group. A single long-term stress model was used to induce PTSD, and a cell phone was used to induce cell phone electromagnetic waves. The duration of cell phone radiation was 28 days and 50 min per day. Spatial memory was assessed with the Morris water maze. The anxiety was evaluated by open field test. The expression levels of Bcl2 and BAX genes in hippocampal tissue were measured by quantitative real-time polymerase chain reaction (RT-qPCR).
Results: Spatial memory was significantly reduced in the naive and electromagnetic wave + PTSD groups compared to the naive group whereas the anxiety was significantly increased. Chronic exposure to mobile phone waves did not significantly alter the performance of animals in the water maze and open field test compared to controls. The ratio of Bax to Bcl-2 gene expression was higher in the naive and electromagnetic wave PTSD groups than the naive group
Conclusion: Cell phone radiation, for 28 days and 50 minutes a day, did not have a synergistic effect with post-traumatic stress disorder on spatial memory and anxiety in rats, as well as indicators of neuronal death in their hippocampus.
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| Keywords: Post-traumatic stress disorder, electromagnetic waves, cell phone, Neural apoptosis, hippocampus |
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Full-Text [PDF 816 kb]
(128 Downloads)
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Type of Study: Original Research |
Subject:
Neuroscience
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