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The effect of a period of high-intensity interval training on serum levels of mitsugumin 53 (MG53) and its relationship with dyslipidemia and insulin resistance index in overweight/obese women
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Fahimeh Kazemi *    , Sahel Teimouri |
| Department of Exercise Physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran |
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Abstract: (12 Views) |
Introduction: Mitsugumin 53 (MG53) is a myokine associated with obesity. The present study aimed to determine the effect of a period of high-intensity interval training (HIIT) on serum levels of MG53 and its relationship with dyslipidemia and insulin resistance index (HOMA-IR) in overweight/obese women.
Methods: In a quasi-experimental study, 24 volunteer overweight or obese female students were randomly divided into two groups of 12: control and exercise. The training group performed HIIT for 7 weeks (three sessions per week). 24 hours before the experimental period and 48 hours after the last training session, BMI and blood samples related to MG53, glucose, insulin, and blood lipids, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and total cholesterol (TC) were measured; the relevant formula also estimated low-density lipoprotein (LDL-C) and insulin resistance index (HOMA-IR). Two-way repeated measures analysis of variance and the Pearson correlation coefficient test were used to analyze the data.
Results: MG53 of the training group decreased significantly in the post-test (0.65 ± 0.07) compared to the pre-test (0.74 ± 0.04) (p = 0.003). Also, there was a significant positive correlation between changes in MG53 and changes in BMI (p = 0.012), LDL-C (p = 0.059), and HOMA-IR (p = 0.041) in the exercise group, and a significant negative correlation between changes in MG53 and changes in HDL-C in the exercise group (p = 0.054), so that MG53 decreased in parallel with the decrease in BMI, LDL-C, and HOMA-IR and parallel with the increase in HDL-C.
Conclusion: It seems that a period of HIIT can improve serum levels of MG53 in overweight/obese women, consistent with improvements in dyslipidemia and HOMA-IR.
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| Keywords: Overweight/obesity, exercise training, blood lipids, myokine mitsugumin 53, insulin resistance |
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Full-Text [PDF 1031 kb]
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Type of Study: Original Research |
Subject:
Endocrine
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