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Five choice serial reaction time task for assessing cognitive functions in animal models
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Saeideh Baradaran   , Elham Alaee , Elmira Beirami , Hamid Gholami PourBadie  , Hossein Azizi , Mohammad Sayyah * |
| Department of Physiology and Pharmacology Pasteur Institute of Iran, Tehran, Iran |
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Abstract: (131 Views) |
Investigating deficits in attention and response inhibition, and their role in psychiatric disorders, requires precise laboratory techniques. The 5-Choice Serial Reaction Time (5-CSRT) task is a common method for measuring visual attention processes in rodents and is frequently used to study impulsivity and attentiveness in these animals. This test evaluates the effects of pharmacological treatments and neurodegenerative damage on various aspects of attentional control, including sustained, selective, and divided attention. It also explores the involvement of neural systems linked to attention and their relevance to behavioral-psychological disorders. Collected data can determine whether other factors—such as sedatives, motivational deficits, or motor impairments—contribute to functional changes. The adaptability of this test can be enhanced through pharmacological, molecular, and genetic techniques. In this paradigm, subjects must detect random visual stimuli presented in one of five locations in a chamber over numerous trials. Animals undergo daily 30-minute training sessions for 30–40 days to learn appropriately timed responses for reward acquisition. Incorrect responses—such as failing to respond, selecting the wrong location, or responding at inappropriate times—result in a brief time-out period of darkness (as punishment) with no reward provided. Results from this task clarify the role of specific neural systems in regulating attention and impulsivity, as well as their association with disorders such as ADHD and neurodegenerative diseases. This review examines the historical development of the 5-CSRTT as a robust tool in clinical and laboratory research, the neurobehavioral parameters it assesses, and its experimental design and procedural stages.
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| Keywords: Five-Choice Serial Reaction Time Test, Impulsivity, Attention |
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Full-Text [PDF 1244 kb]
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Type of Study: Review Article -by invitation |
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