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The role of central histaminergic system in cholecystokinin-induced hypophagia in broilers
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Vahid Hamedian Asl   , Morteza Zendehdel *  , Keyvan Hasani , Hamed Zarei , Kimia Mahdavi |
| Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran |
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Abstract: (74 Views) |
Background and Aim: Despite proving the role of cholecystokinin (CCK) and the central histaminergic system in the regulation of food intake in birds and mammals, no findings have been presented regarding the interaction between these two systems. Therefore, the present study was designed and implemented with the aim of investigating the role of central histaminergic receptors in changes in food intake caused by CCK8S administration in broiler chickens.
Methods: For this purpose, chicks were injected intracerebroventricularly (ICV) at the age of five days. In the first experiment, control solution and CCK8S in doses of 0.25, 0.5, and 1 nmol were administered, and in the second experiment, control solution, CCK8S (1 nmol), α-FMH (histamine synthesis inhibitor) and CCK8S + α-FMH were administrated. Experiments 3-5 were similar to the second experiment except that instead of α-FMH, chlorpheniramine (H1 receptor antagonist), famotidine (H2 receptor antagonist) and thiopramide (H3 receptor antagonist) were injected. Then, cumulative food consumption was measured at 30, 60, and 120 minutes after injection.
Results: According to the obtained results, CCK8S injection decreased food consumption in chickens in a dose-dependent manner (p ≤ 0.05). Also, despite the ineffectiveness of separate injection of sub-effective doses of histamine receptor antagonists, the combined injection of α-FMH and chlorpheniramine with CCK8S significantly weakened the reduction of food intake induced by CCK (p ≤ 0.05).
Conclusion: These findings indicate that the hypophagic effects of CCK8S may be mediated via H1 receptors in broilers.
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| Keywords: Food intake, Broiler, Histaminergic system, Cholecystokinin |
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Full-Text [PDF 1043 kb]
(67 Downloads)
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Type of Study: Original Research |
Subject:
Neuroscience
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