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Single nucleotide polymorphisms in renin-angiotensin pathway-related miRNAs in clear cell renal carcinoma: A bioinformatics study
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Pegah Mousavi   , Soudabeh Sabetian , Aghdas Dehghani *  |
| Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran |
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Abstract: (391 Views) |
Clear cell renal carcinoma (KIRC) is the most common type of kidney cancer and has a poor prognosis with a low overall survival rate, resulting in thousands of deaths per year. There is a critical need to understand the molecular mechanisms of KIRC to identify new biomarkers. the renin-angiotensin system (RAS), known for its regulatory role in cardiovascular, renal, and tissue functions, has been demonstrated in numerous studies to be significantly involved in the pathogenesis of malignant tumors. While microRNA has been studied as a biomarker and prognostic tool for different cancers, it remains challenging to explore its role in kidney cancer because a single miRNA can target multiple genes within biological networks and pathways. The aim of this study is to theoretically analyze the potential impact of single nucleotide polymorphisms (SNPs) in miRNAs related to genes involved in the renin-angiotensin pathway in clear cell renal carcinoma. To accomplish this goal, several online tools, including miRTarBase, CancerMIRNome, miRNASNPV3, UALCAN, and Ncpath were used.This study provides a list of confirmed SNPs that can affect the expression or function of renin-angiotensin pathway-related miRNAs in clear cell renal cell carcinoma disease for a prospective laboratory study in the diagnosis and treatment management of clear cell renal cell carcinoma.
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| Keywords: Clear cell renal carcinoma, Single nucleotide polymorphisms, Renin-angiotensin system, miRNA |
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Full-Text [PDF 1305 kb]
(151 Downloads)
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Type of Study: Review Article -by invitation |
Subject:
Kidney and Urinary tracts
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