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:: Volume 8 - ::
Ir J Physiol Pharmacol 2025, 8 - : 42-56 Back to browse issues page
Exploring the anticonvulsant effects of melatoninergic system: an updated review
Ali Mandegary * , Farzad Rafiei , Saina Sadeghipour , Seyed Mohammad Hossieni
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (123 Views)
Epilepsy is a chronic neurological disorder characterized by recurrent seizures. Although there are many medications available to control epilepsy, drug resistance and drug toxicity still pose significant challenges for managing this condition. Combination therapy and targeting different pathways involved in seizures can be a suitable strategy to reduce drug side effects and increase its efficacy. There are multiple reports on the relationship between epilepsy and melatonin, a neurohormone secreted by the pineal gland involved in regulating circadian rhythms. This review article will discuss recent advances in stimulating the melatonergic pathway with melatonin and melatonin agonists in the treatment of epilepsy. A comprehensive understanding of the relationship between melatonergic pathways and seizure could pave the way for future studies in treating epileptic disorders.

Keywords: ‎Seizure, Circadian, Epilepsy, Melatonin
Full-Text [PDF 2093 kb]   (54 Downloads)    
Type of Study: Review Article -by invitation | Subject: Neuroscience
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Mandegary A, Rafiei F, Sadeghipour S, Hossieni S M. Exploring the anticonvulsant effects of melatoninergic system: an updated review. Ir J Physiol Pharmacol 2025; 8 :42-56
URL: http://ijpp.phypha.ir/article-1-699-en.html

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Volume 8 - Back to browse issues page
مجله فیزیولوژی و فارماکولوژی ایران Iranian Journal of Physiology and Pharmacology
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