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Effect of monophosphoryl lipid-A on spatial memory of rats
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Maryam Hooshmand   , Ahmad Asoodeh*  , Mohamad Sayyah * , Hamid Gholami Pourbadie , Mahbobeh Kamranimehni |
| Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran |
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Abstract: (249 Views) |
Background and Aim: Neurodegenerative diseases such as Alzheimer's disease are the most common cause of memory impairment worldwide. No effective drug treatment has been found to improve the memory deficit and quality of life of these patients. Considering the effects of MPL on improving memory in Alzheimer's disease and hippocampal ischemia, this study investigated the effect of monophosphoryl lipid A (MPL) on the spatial memory of rats.
Methods: This study was conducted on 48 adult male Wistar rats (45-day-old) weighing 250-270 grams, which were randomly divided into two groups of “7 days” and “28 days”. Each group was divided into three subgroups (n = 8) including control, sham, and drug. The spatial learning and memory were assessed by the Morris water maze. Animals were trained to find the hidden platform in the maze for five days and 4 sessions every day. The drug was injected into the lateral cerebral ventricle at a dose of 1 µg per 5 µL per rat, 20 min after surgery. The time spent and the distance traveled in the target quadrant were assessed on the seventh and twenty-eighth days after the last day of learning.
Results: No significant difference was found between the groups in the time spent and distance traveled in the target quadrant during the learning phase. Furthermore, there was no significant difference between groups in memory recall at both 7 days and 28 days after the training period (p > 0.05).
Conclusion: In our study, MPL 1 µg/5 µL/rat did not affect the spatial memory of rats.
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| Keywords: Monophosphoryl lipid a, spatial memory, Morris water maze |
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Full-Text [PDF 1046 kb]
(198 Downloads)
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Type of Study: Original Research |
Subject:
Neuroscience
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