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The effect of Vitamin D3 on biochemical and histopathological changes, and oxidative stress in male Wistar rats induced by chronic non-bacterial prostatitis
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Fatemeh Yousefzadeh Roshan   , Mahmood Ahmadi-hamedani *  , Abbas Javaheri Vayeghan , Hamid Reza Moslemi |
| Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran |
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Abstract: (2413 Views) |
Background and aims: Inflammatory cytokines and oxidative stress play an important role in the pathogenesis of non-bacterial chronic prostatitis. Given the role of vitamin D3 in balancing inflammatory and anti-inflammatory cytokines and having antioxidant properties, this study aimed to evaluate the effect of vitamin D3 on biochemical, histopathological and oxidative changes in Wistar male rats induced by chronic non-bacterial prostatitis (CNP).
Methods: Twenty four adult male Wistar rats were divided into healthy, CNP without treatment, and two treatment groups including CNP + cernilton and CNP + D3 groups. CNP was induced by single intraprostatic injection of 3% carrageenan. Rats received orally cernilton 100 mg/kg and Vitamin D3 5µg/kg one week after CNP induction for 21 days. Prostatic index (PI), Oxidative index (OI), blood urea nitrogen (BUN), creatinine, calcium and histopathological changes were compared between groups.
Results: Oral administration of cernilton and Vitamin D3 in the treatment groups significantly
(p < 0.05) decreased prostatic and oxidative stress indices and serum creatinine compared to the untreated group. Vitamin D3 significantly increased (p < 0.05) serum calcium concentration compared to the untreated group. No significant differences were observed between the treatment groups and the untreated group in the blood urea nitrogen concentration. In a quantitative evaluation of histopathological results, a significant decrease in mean cell wall hyperplasia, inflammation, and total hyperplasia and inflammation was observed in the vitamin D3 treated group compared to the untreated group.
Conclusion: Our study indicates that Vitamin D3 shows protective effects on CNP induced by carrageenan in rats due to its antioxidant and anti-inflammatory properties. |
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| Keywords: Oxidative stress, Chronic nonbacterial prostatitis, Carrageenan, Vitamin D3, Histopathology |
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Full-Text [PDF 925 kb]
(758 Downloads)
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Type of Study: Original Research |
Subject:
Kidney and Urinary tracts
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