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Exploring the potential effects of cannabidiol on the development of morphine sensitization induced by forced swim stress in rats
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Hadi Semizeh   , Morteza Zendehdel *  , Abbas Haghparast |
| Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran |
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Abstract: (73 Views) |
Background and Aim: Cannabidiol, a non-psychoactive constituent of cannabis, has been proposed to modulate opioid sensitivity, but its mechanisms remain unclear. Stress is a key factor influencing opioid responses, yet its interaction with cannabidiol is not fully understood. This study investigated the effect of cannabidiol on morphine sensitization induced by forced swim stress in rats.
Methods: Male Wistar rats received intracerebroventricular cannabidiol (10–200 µg/5 µl) with morphine (1 mg/kg, s.c.) or saline, in the presence or absence of forced swim stress for three days. Antinociceptive responses were assessed on day 9 using the tail-flick test. Data were analyzed using two-way repeated measures ANOVA followed by Bonferroni post hoc test.
Results: Forced swim stress combined with a subthreshold dose of morphine induced significant sensitization, whereas either treatment alone had no effect. Cannabidiol attenuated morphine sensitization under stress conditions. In contrast, in the absence of stress, cannabidiol increased morphine sensitivity in a dose-dependent manner.
Conclusion: Cannabidiol modulates morphine sensitization in a stress-dependent manner. However, intracerebroventricular administration and reliance on a single behavioral test limit the generalizability of these findings.
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| Keywords: Forced swim stress, Sensitization, Rat, Cannabidiol, Morphine |
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Full-Text [PDF 1824 kb]
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Type of Study: Original Research |
Subject:
Neuroscience
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