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The effect of eight weeks of aerobic training on serum Nrf2 concentration and redox status markers in women with type 2 diabetes
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Hanieh Panahyab *    , Reza Farzizadeh , Farnaz Seifi Asagshahr |
| Department of Exercise Physiology, Faculty of Educational Sciences and Physiology, University of Mohaghegh Ardabili, Ardabili, Iran |
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Abstract: (86 Views) |
Background and objective: Type 2 diabetes, as one of the most prevalent metabolic diseases, is associated with an imbalance in redox balance and increased oxidative stress, and the transcription factor Nrf2, as a key regulator of cellular antioxidant and defense pathways, plays a central role in modulating this stress. The present study was conducted to investigate the effect of 8 weeks of aerobic training on serum Nrf2 concentration and redox status markers in women with type 2 diabetes.
Methods: Twenty women with type 2 diabetes (aged 40-60 years) were randomly assigned to either a control group (n = 10) or an aerobic training group (n = 10). The training group performed an 8-week treadmill running program (3 sessions per week) with progressively increasing intensity from 40% to 70% of maximum heart rate. Blood samples were collected 24 hours before and 48 hours after the intervention period. Serum levels of Nrf2, reduced glutathione (GSH), and oxidized glutathione (GSSG) were measured, and the GSH/GSSG ratio was calculated. A paired-samples t-test was used to compare within-group changes, and analysis of covariance (ANCOVA) was applied to compare between-group differences.
Results: The results of the present study showed a significant increase in Nrf2 (p = 0.008), GSH (p = 0.004), GSH/GSSG ratio (p = 0.011), and a significant decrease in GSSG (p = 0.017) after 8 weeks of training in the aerobic group. However, in the control group, no significant difference was observed in any of the variables (p ≥ 0.05). Also, according to the analysis of covariance test with control of the pretest variable, a significant difference was observed between the two aerobic and control groups in GSH, GSSG, and GSH/GSSG ratio (p ≤ 0.05).
Conclusion: Overall, the results of this study indicate that aerobic exercise can serve as an effective strategy for improving redox status and reducing oxidative stress in patients with type 2 diabetes. These findings highlight the importance of incorporating aerobic exercise into diabetes management programs and suggest that exercise is beneficial not only for glycemic control but also for improving metabolic health and reducing diabetes-related complications.
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| Keywords: Diabetes, Aerobic exercise, Nuclear factor erythroid 2-related factor 2 (Nrf2), Reduced glutathione (GSH), Oxidized glutathione (GSSG) |
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Full-Text [PDF 801 kb]
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Type of Study: Original Research |
Subject:
Exercise physiology
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