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Protective effects of ghrelin against hypoxia, apoptosis, and inflammation in various tissues and stem cells
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Hadi Feizi *    , Mohammad Reza Alipour , Mohsen Alipour |
| Department of Physiology, School of Medicine, Zanjan University of Medical Sciences |
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Abstract: (146 Views) |
Ghrelin is a 28-amino-acid peptide that is primarily secreted from the fundus of the stomach. Initially, it was introduced as a stimulant for growth hormone secretion and a regulator of appetite and metabolism. Later studies showed that ghrelin receptors are expressed in various tissues and can have more diverse effects. In in vitro studies, it has been found that ghrelin can prevent tissue damage. Administration of ghrelin to laboratory animals under hypoxic conditions demonstrated that it could reduce the complications of environmental hypoxia, especially in the lungs of animals. The anti-apoptotic effects of ghrelin have been well established in both in vitro and in vivo studies. Ghrelin, in addition to its proliferative effects on stem cells, can also induce their differentiation, which has led a wide range of researchers to focus on its application in cell therapy. Due to its protective, anti-apoptotic, and inductive properties, it has attracted attention as a co-treatment option in stem cell transplant.
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| Keywords: Apoptosis, Stem cells, Ghrelin, Hypoxia |
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Full-Text [PDF 1418 kb]
(70 Downloads)
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Type of Study: Review Article -by invitation |
Subject:
Endocrine
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