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Role of nitrergic systems in feed intake induced by nociceptin/orphanin FQ in neonatal meat-type chickens
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Shokoufe Abolghasempour   , Negar Panahi *  , Hasan Gilanpour , Morteza Zendedel , Alireza Jahandideh |
| Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran |
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Abstract: (1022 Views) |
Background and Aim: Various neurochemical pathways participate in regulating food intake in mammals and birds. The nociceptin/orphanin FQ (N/OFQ) is involved in the central nervous system and increass food intake. Nitric oxide (NO) is a hypophagic agent in birds. The present study aimed to investigate the central nociceptin/orphanin FQ (N/OFQ) effects and its interaction with nitrergic systems on feeding behavior in neonatal chickens.
Methods: Seventy-two neonatal male broiler-type (Ross 308) chickens were divided randomly into two experimental groups. Each experiment had a control group and three treatment groups (n = 12). In all experiments, 3-hour food-deprived (FD3) birds received intracerebroventricular (ICV) injections either diluent (control) or drug solution. Then the birds had ad libitum access to the food and fresh water, and then cumulative food intake (g) was measured based on the percentage of the body. In the first experiment, chickens received ICV injection of L-arginine (NO precursor, 400 nmol), N/OFQ (16 nmol), and L-arginine with N/OFQ. L-NAME (NO synthase inhibitor, 200 nmol), N/OFQ (16 nmol), and L-NAME + N/OFQ were injected in the second experiment.
Results: ICV injection of N/OFQ significantly increased food intake (p < 0.05). Injection of the N/OFQ + L-arginine significantly attenuated the hyperphagic effect induced by N/OFQ in neonatal broilers (p < 0.05). Conversely, injection of the N/OFQ + L-NAME significantly decreased the hyperphagic effect induced by N/OFQ (p < 0.05).
Conclusion: Our findings suggest that the hyperphagic effect of central N/OFQ in FD3 neonatal layer-type chicken is probably mediated by nitric oxide.
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| Keywords: Food Intake, L-arginine, Broiler Chicken |
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Full-Text [PDF 560 kb]
(859 Downloads)
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Type of Study: Review Article -by invitation |
Subject:
Neuroscience
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