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The effect of moderate intensity endurance training on some fatty liver and metabolic indices in diabetic women with non-alcoholic fatty liver
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Afsaneh Astinchap   , Amirabbas Monazzami *  , Zohreh Rahimi , Mehrali Rahimi |
| Department of Sport Physiology , Faculty of Sport Science, Razi University, Kermanshah, Iran |
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Abstract: (1836 Views) |
Background and aims: Research on the effects of endurance training on fibroblast growth factor 21 (FGF21) and βKlotho protein expression in patient with nonalcoholic fatty liver disease (NAFLD) is limited. We aimed to determine effects of eight weeks endurance training with moderate intensity on FGF21 and βKlotho protein expression in diabetic women with NAFLD.
Methods: Thirty diabetic women (age 53 ± 7, height 158 ± 4, weight 75 ± 9) with NAFLD participated in this study Subjects were randomly divided into two groups of control (n = 15) and exercise (n = 15). The training was performed by running in each session for 30-45 min with 60-70% of the heart rate reserve and three sessions per week for eight weeks. Control group did not perform any exercise program. Rockport walking test and ELISA technique were used to measure VO2max and βKlotho and FGF21 protein expression, respectively. Two-way ANOVA test with repeated measures and p < 0.05 was used to determine the significant differences.
Results: Except for βKlotho serum level, none of the other variables of the control group showed significant difference in pre and post training. However, in the training group, weight, fat percent, body mass index, Waist to hip ratio, insulin, glucose, βKlotho and FGF21 levels were significantly changed after training (p < 0.05). A significant difference was observed between control and training groups in βKlotho and FGF21 levels (p < 0.05).
Conclusion: Endurance training could improve imbalance of FGF21 and βKlotho protein expression in women with type 2 diabetes and NAFLD.
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| Keywords: βKlotho, Endurance training, Type 2 diabetes, Fibroblast growth factor 21, Insulin resistance |
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Full-Text [PDF 934 kb]
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Type of Study: Original Research |
Subject:
Exercise physiology
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