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Ir J Physiol Pharmacol 2019, 3(4): 287-280 Back to browse issues page
Effect of ethanoic extract of Cinnamomum Verum on serum sorbitol dehydrogenase and aldose reductase activity in the lens and testis of rats with diabetes mellitus
Gholamali Jelodar * , Nahid Syamard
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Abstract:   (402 Views)
Background and aims: Diabetes mellitus is accompanied by many complications in eye, kidney, nervous, and reproduction systems. Polyol pathway is one of the mechanisms involved in the development of diabetic complications due to increased activity of aldose reductase (AR) and sorbitol dehydrogenase (SDH). Inhibiting AR can be a target to prevent diabetes complications. This study aimed to evaluate the effect of cinnamon hydroalcoholic extract (CE) on serum SDH level and AR in the lens and testis of diabetic rats.
Methods: Forty-eight male rats were classified into six groups as control (vehicle), treatment control I & II (250 or 350 mg/kg/day of CE, respectively), diabetic control (vehicle), and treatment groups I & II (250 or 350 mg/kg/day of CE respectively). Rats treated for 30 days. Diabetes mellitus was induced by a single dose of streptozotocin. Serum SDH, and AR level in the lens and testis were measured.
Results: Diabetes significantly increased the level of SDH and AR. Cinnamon extracts significantly reduced theAR level in the testis and lens and serum SDH in the treatment group compared to the DC group (P<0.0001). There was no significant difference between control groups.
Conclusion: Cinnamon extracts may ameliorate some complications of the chronic diabetes through decreasing the level of SDH and AR.
Keywords: Aldose reductase, Cinnamon, Diabetes, Sorbitol dehydrogenase
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Type of Study: Original Research | Subject: Endocrine
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Jelodar G, Syamard N. Effect of ethanoic extract of Cinnamomum Verum on serum sorbitol dehydrogenase and aldose reductase activity in the lens and testis of rats with diabetes mellitus. Ir J Physiol Pharmacol. 2019; 3 (4) :287-280
URL: http://ijpp.phypha.ir/article-1-423-en.html


Volume 3, Issue 4 (12-2019) Back to browse issues page
مجله فیزیولوژی و فارماکولوژی ایران Iranian Journal of Physiology and Pharmacology
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