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Exploring the anticonvulsant effects of melatoninergic system: an updated review
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Ali Mandegary *    , Farzad Rafiei , Saina Sadeghipour , Seyed Mohammad Hossieni |
| Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
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Abstract: (227 Views) |
Epilepsy is a chronic neurological disorder characterized by recurrent seizures. Although there are many medications available to control epilepsy, drug resistance and drug toxicity still pose significant challenges for managing this condition. Combination therapy and targeting different pathways involved in seizures can be a suitable strategy to reduce drug side effects and increase its efficacy. There are multiple reports on the relationship between epilepsy and melatonin, a neurohormone secreted by the pineal gland involved in regulating circadian rhythms. This review article will discuss recent advances in stimulating the melatonergic pathway with melatonin and melatonin agonists in the treatment of epilepsy. A comprehensive understanding of the relationship between melatonergic pathways and seizure could pave the way for future studies in treating epileptic disorders.
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| Keywords: Seizure, Circadian, Epilepsy, Melatonin |
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Full-Text [PDF 2093 kb]
(97 Downloads)
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Type of Study: Review Article -by invitation |
Subject:
Neuroscience
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