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Exposure to morphine during embryonic period impairs learning in attention task in rats
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Elham Alaee   , Hossein Azizi *  |
| Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran |
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Abstract: (216 Views) |
Morphine passes through the placenta and selectively accumulates in the nervous tissues of the fetus. In the present study, the effect of exposure to morphine during embryonic period on cognitive functions such as attention and impulsive behaviors in male offspring has been investigated.
Methods: Female rats received morphine subcutaneously twice a day in doses of 5 and 10 mg/kg during pregnancy (days 11 to 18). In the behavioral study, the 5-CSRTT (5-choice serial reaction time task) was used.
Results: In the training phase of the behavioral test, the prenatal morphine group needed more days to learn the test than the saline group. In the baseline condition, the animals exposed to morphine in the embryonic period showed more impulsive and obsessive responses compared to the saline group.
Conclusion: Behavioral results show a direct effect of exposure to morphine during embryonic period on delayed learning and impulsive behaviors in adulthood. |
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| Keywords: Attention, Embryonic period, Cognition, Morphine, Learning |
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Full-Text [PDF 879 kb]
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Type of Study: Original Research |
Subject:
Neuroscience
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