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:: Volume 6 - ::
Ir J Physiol Pharmacol 2022, 6 - : 220-228 Back to browse issues page
Synergistic effects of neuromedin S with dopamine and noradrenaline on food intake in 5-day-old chickens
Kourosh Gholami Ahmadabadi , Morteza Zendehdel * , Bita Vazir , Vahab Babapour , Ahmad Asghari
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Abstract:   (382 Views)
Background and aims: Dopamine and noradrenaline  play an important role in food intake control. On the other hand, neuromedin S (NMS) decreases food intake. This study aimed to investigate the synergistic effects of dopamine and noradrenaline  with a sub-effective dose of NMS on food intake in neonatal chickens.
Methods: A total of 132 five-old-day chicks were randomly divided into three experimental groups. Each experiment had a control group and three treatment groups (n = 11 in each group). Three-hour food-deprived birds received intracerebroventricular injections of either control diluent or drug solution. In the first experiment, control solution, NMS (0.25 nmol), L-DOPA (dopamine precursor; 125 nmol), and NMS + L-DOPA were injected.  In the second experiment, control solution, NMS (0.25 nmol), dopamine (10 nmol), and NMS + dopamine were injected. In the third experiment, control solution, NMS (0.25 nmol), noradrenaline (37.5 nmol), and , NMS + noradrenaline were injected.
Results: Although the injection of NMS with a dose of 0.25 (sub-effective dose), L-dopa with a dose of 125
(sub-effective dose), dopamine with a dose of 10 (sub-effective dose), and noradrenaline with a dose of 37.5 (sub-effective dose) had no effect on food intake (p < 0.05), the co-injection of Neuromedin S with L-dopa or dopamine or noradrenaline decreased food intake (p < 0.05).

Conclusion: According to the results of the present study, there is probably a synergistic effect between NMS with dopamine and noradrenaline on food intake control of neonatal chicks.
 
Keywords: Food Intake, Chicken, Dopamine, Noradrenaline, NMS
Full-Text [PDF 1056 kb]   (582 Downloads)    
Type of Study: Original Research | Subject: Neuroscience
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Gholami Ahmadabadi K, Zendehdel M, Vazir B, Babapour V, Asghari A. Synergistic effects of neuromedin S with dopamine and noradrenaline on food intake in 5-day-old chickens. Ir J Physiol Pharmacol 2022; 6 :220-228
URL: http://ijpp.phypha.ir/article-1-596-en.html


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Volume 6 - Back to browse issues page
مجله فیزیولوژی و فارماکولوژی ایران Iranian Journal of Physiology and Pharmacology
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