Synergistic effects of neuromedin S with dopamine and noradrenaline on food intake in 5-day-old chickens
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Kourosh Gholami Ahmadabadi , Morteza Zendehdel * , Bita Vazir , Vahab Babapour , Ahmad Asghari |
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran |
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Abstract: (382 Views) |
Background and aims: Dopamine and noradrenaline play an important role in food intake control. On the other hand, neuromedin S (NMS) decreases food intake. This study aimed to investigate the synergistic effects of dopamine and noradrenaline with a sub-effective dose of NMS on food intake in neonatal chickens.
Methods: A total of 132 five-old-day chicks were randomly divided into three experimental groups. Each experiment had a control group and three treatment groups (n = 11 in each group). Three-hour food-deprived birds received intracerebroventricular injections of either control diluent or drug solution. In the first experiment, control solution, NMS (0.25 nmol), L-DOPA (dopamine precursor; 125 nmol), and NMS + L-DOPA were injected. In the second experiment, control solution, NMS (0.25 nmol), dopamine (10 nmol), and NMS + dopamine were injected. In the third experiment, control solution, NMS (0.25 nmol), noradrenaline (37.5 nmol), and , NMS + noradrenaline were injected.
Results: Although the injection of NMS with a dose of 0.25 (sub-effective dose), L-dopa with a dose of 125
(sub-effective dose), dopamine with a dose of 10 (sub-effective dose), and noradrenaline with a dose of 37.5 (sub-effective dose) had no effect on food intake (p < 0.05), the co-injection of Neuromedin S with L-dopa or dopamine or noradrenaline decreased food intake (p < 0.05).
Conclusion: According to the results of the present study, there is probably a synergistic effect between NMS with dopamine and noradrenaline on food intake control of neonatal chicks.
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Keywords: Food Intake, Chicken, Dopamine, Noradrenaline, NMS |
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Full-Text [PDF 1056 kb]
(582 Downloads)
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Type of Study: Original Research |
Subject:
Neuroscience
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