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Investigating the short-term and long-term effects of Pam3cys on the spatial memory of rats
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Mahbobeh Kamrani Mehni   , Maryam Hooshmand , Mohamamd Sayyah *  , Hamid Gholami Pourbadie* , Morteza Zendehdel |
| Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran |
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Abstract: (164 Views) |
Background and Aim: Pam3cys is a weak agonist of toll-like receptors type 1 and 2 and is able to inhibit learning and memory impairment in an animal model of Alzheimer's disease by inhibiting the secretion of inflammatory cytokines and increasing the secretion of anti-inflammatory cytokines. This arrangement is effective in improving memory performance. Considering the improving effect of Pam3cys on learning and memory impairment of Alzheimer's disease in an animal model, in this study, the effect of Pam3cys drug alone on the spatial memory of rats was investigated
Methods: In this experimental study, 48 male Wistar rats (age, 45-days old; weight, 220-270 g) were randomly divided into six groups (n = 8) as follows: There were two control groups of 7 and 28 days, two sham groups of 7 and 28 days, and two drug groups of 7 and 28 days. The spatial memory learning process of all mice was done using the Morris water maze for five days and four training sessions every day to find the hidden platform. At the last day of the learning period, the drug was injected intraventricularly with phosphate buffer (sham group) or Pam3cys (1 μg/5μl per mouse). 7 and 28 days after the injection, the memory of the rats was measured by measuring the time, speed and distance traveled in the target quarter of the maze.
Results: In the learning phase, there was no significant difference between the groups in terms of the time spent and the distance traveled in the target quarter of the circle. At 7 and 28 days after the learning period, there was no significant difference between the groups in terms of memory recall between the group of animals that received Pam3cys and the group of control animals as well as sham animals without receiving the drug (p > 0.05).
Conclusion: Pam3cys with the dose used in this study has no effect on the spatial memory performance of rats in the short and long term. Also, due to the lack of effect on healthy rats, it can be used as a safe medicine in disease conditions.
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| Keywords: Pam3cys, spatial memory, Morris water maze, Rat |
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Full-Text [PDF 1266 kb]
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Type of Study: Original Research |
Subject:
Neuroscience
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