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:: Volume 6 - ::
Ir J Physiol Pharmacol 2022, 6 - : 201-210 Back to browse issues page
Effect of aerobic training and aged garlic extract supplementation on TLR4 and NFƙB gene expression in visceral adipose tissue and lipid profile changes in obese male rats
Parisa Khabiri , Mohammad Rahman Rahimi * , Iraj Rashidi , Seyed Ershad Nedaei
Department of Exercise Physiology, University of Kurdistan, Sanandaj, Iran
Abstract:   (437 Views)
Background and Aim: Chronic low-grade inflammation is a common condition in obesity. The aim of the present study was to investigate the effects of aged garlic extract and aerobic training on TLR4/NFƙB inflammatory signaling pathway gene expression in obese male rats.
Methods: Forty male Sprague-Dawley rats were subjected to high-fat diet (n = 32) and standard diet group (n = 8) for 9 weeks. After inducing obesity in the rats fed high-fat diet, the rats of this group were divided into four subgroups (n = 8), including the obese control (OC), the supplemented with aged garlic extract (AGE), the aerobic training (AT), and the supplemented with aged garlic extract + aerobic training (AGE + AT). The rats in the standard diet group also continued their diet for 8 weeks and interventions continued for 8 weeks. AGE was fed to rats once daily at a dose of 600 mg/kg by gavage. AT also included running on a treadmill five days a week. The TLR4 and NFƙB gene expression was measured by Real-time PCR and lipid profile changes evaluated in plasma.
Results: All interventions led to a significant decrease in TLR4 and NFƙB gene expression in visceral fat, as well as improving the lipid profile of obese rats (p = 0.001). TLR4 reduction was higher in AGE + AT group (p = 0.001). On the other hand, AGE and AGE + AT caused a greater decrease in NFƙB gene expression compared to AT (p = 0.001). AGE + AT also improved the lipid profile more compared to other interventions (p = 0.001).
Conclusion: The combining of interventions is more effective in reducing TLR4 and NFƙB gene expression in visceral fat as well as improving lipid profile.
 
Keywords: ‎Aerobic training, Obesity, Aged garlic extract, NFƙB, TLR4
Full-Text [PDF 1136 kb]   (660 Downloads)    
Type of Study: Original Research | Subject: Endocrine
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Khabiri P, Rahimi M R, Rashidi I, Nedaei S E. Effect of aerobic training and aged garlic extract supplementation on TLR4 and NFƙB gene expression in visceral adipose tissue and lipid profile changes in obese male rats. Ir J Physiol Pharmacol 2022; 6 :201-210
URL: http://ijpp.phypha.ir/article-1-594-en.html


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Volume 6 - Back to browse issues page
مجله فیزیولوژی و فارماکولوژی ایران Iranian Journal of Physiology and Pharmacology
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