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Deep brain stimulation as a therapeutic approach in Alzheimer’s disease
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Fatemeh Bakhtiarzadeh   , Koorosh Shahpasand , Yaghoub Fathollahi , Amir Shojaei , Javad Mirnajafi-Zadeh *  |
| Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran |
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Abstract: (885 Views) |
Alzheimer's disease is the most common cause of dementia in middle age and aging. It is the third leading cause of death among the elderly. Alzheimer's disease is a neurodegenerative disorder, characterized by attention deficits, memory and learning impairment. Many researches try to find new alternative treatment options for Alzheimer's disease. Deep brain stimulation (DBS) is one of the new therapies for treating this disease. Early studies have shown that applying DBS in the hippocampus, meynert nucleus, fornix, and entorhinal cortex of patients as well as experimental Alzheimer-like models in animals can improve learning abnormalities and increase the volume of the hippocampus. The mechanisms responsible for this effect are still unknown, but maybe DBS effect through changes in neurotransmitters and neuromodulators release, thereby regulates the neuronal activities. In this article, we first review the common drug treatments for Alzheimer's disease and their complications, and then review the effect of DBS on the Alzheimer's patient and the animal model of Alzheimer's, and finally discuss the possible mechanisms involved in these therapeutic effects and changes in neurotransmitters.
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| Keywords: Alzheimer disease, Deep brain stimulation, Learning and memory, Cognitive disorder |
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Full-Text [PDF 1075 kb]
(684 Downloads)
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Type of Study: Original Research |
Subject:
Neuroscience
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