fa بررسی اثرات درمانی عصاره آبی سینامون (Cinnamomum zeylanicum) بر نقایص ادراکی در مدل حیوانی بیماری آلزایمر علوم اعصاب Neuroscience پژوهشي اصیل Original Research <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:99%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"><span style="color:black">زمینه و هدف</span></span></span></b><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"><span style="color:black">: </span></span></span><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:">مطالعات اخیر نشان داده اند گیاه </span></span><i><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">Cinnamomum zeylanicum</span></span></span></i><span style="line-height:99%"><span b="" mitra="" style="font-family:"> دارای فعالیت آنتی‌&shy;اکسیدانی، ضدالتهاب، مهار تجمع بتا</span></span> <span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:">آمیلوئید </span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">(A&beta;)</span></span></span><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"> و پروتئین تاو می‌&shy;باشد. بنابراین به نظر می&shy;رسد این گیاه بتواند عملکرد ادراکی را در مدل آلزایمر موش صحرایی بهبود بخشد. بدین&shy; منظور اثر دوزهای مختلف عصاره آبی این گیاه بر نقص یادگیری فضایی ناشی از </span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">A&beta;_25-35</span></span></span><span style="line-height:99%"><span b="" mitra="" style="font-family:"> در هیپوکامپ موش&shy;های صحرایی با استفاده از ماز آبی موریس مورد بررسی قرار گرفت.</span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:99%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"><span style="color:black">روش&shy;‌ها</span></span></span></b><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"><span style="color:black">: </span></span></span><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:">موش&shy;ها تحت عمل جراحی استریوتاکسی قرار گرفته و تزریق دوطرفه</span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">A&beta;_25-35</span></span></span>_&nbsp;<span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:">در هیپوکامپ آن&shy;ها انجام گردید. یک هفته بعد، عصاره سینامون در دوزهای مختلف (5، 10 و 20 میلی گرم بر کیلوگرم) هر روز نیم ساعت قبل از آزمون ماز آبی موریس به&shy; صورت داخل صفاقی تزریق گردید. حیوانات 5 روز تحت آزمایش قرار گرفتند: 4 روز اول آزمایش به منظور بررسی یادگیری فضایی از سکوی پنهان و در روز پنجم جهت بررسی توانایی حسی، حرکتی و انگیزشی از سکوی آشکار استفاده شد. </span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:99%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"><span style="color:black">یافته‌&shy;ها</span></span></span></b><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"><span style="color:black">: </span></span></span><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:">در گروه </span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">A&beta;</span></span></span><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:">، مدت زمان لازم برای یافتن سکو، مسافت طی شده و زاویه جهت&shy; گیری در مقایسه با گروه کنترل بیشتر و در صد ورود به ربع دایره هدف کمتر بوده است. عصاره سینامون توانست اثر </span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">A&beta;</span></span></span><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"> را به طور معنی&shy;داری کاهش دهد.</span></span> <span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:99%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"><span style="color:black">نتیجه‌گیری</span></span></span></b><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"><span style="color:black">: </span></span></span><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:">نتایج نشان&shy;دهنده اختلال یادگیری در نتیجه تجویز داخل هیپوکامپ </span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">A&beta;_25-35</span></span></span><span style="line-height:99%"><span b="" mitra="" style="font-family:"> و تأثیر سینامون در کاهش سمیت </span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">A&beta;</span></span></span><span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:"> و در نتیجه بهبود یادگیری می&shy;باشند. در مجموع،</span></span> <span lang="FA" style="line-height:99%"><span b="" mitra="" style="font-family:">این مطالعه کارآیی عصاره سینامون را در مقابله با اثرات&nbsp; </span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span new="" roman="" style="font-family:" times="">A&beta;</span></span></span><span style="line-height:99%"><span b="" mitra="" style="font-family:"> تایید می‌&shy;کند.</span></span><span lang="FA" style="font-family:"B Mitra""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><span lang="FA" style="font-size:6.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span></span> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background and aims:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Recent studies have shown <i>Cinnamomum zeylanicum</i> antioxidant/anti-inflammatory activities, and inhibition of tau</span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">accumulation and</span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Amyloid beta (A&beta;) &nbsp;<span style="color:black">&nbsp;aggregation. Therefore, it seems that this plant can improve cognition in rat model of Alzheimer&rsquo;s disease (AD).</span> For this purpose, the ability of an aqueous extract of cinnamon in attenuating A&beta;-induced learning impairment was evaluated in a rat model of AD.<span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Methods:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">A&beta;-protein fragment 25-35 was injected into the CA1 region of rats&rsquo; hippocampus and the effect of different doses of cinnamon extract (5, 10, or 20 mg/kg) on cognitive function was assessed in the Morris water maze. Animals were subjected to 5 days of training; 4 days with the invisible platform to test spatial learning and the 5th day with the visible platform to test motivation and sensorimotor coordination</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">.</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">The results showed an significant increase in escape latency, traveled distance, orientation angle</span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">and decrease in target quadrant entries in A&beta;-received rats. Cinnamon extract was able to significantly reduce the effect of A&beta;<span style="color:black">.</span></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">The results indicates learning and memory impairment in A&beta;_25-35 groups. These impairments were reversed by administration of <i>Cinnamomum zeylanicum </i>extract<i>. </i>Our results suggest that cinnamon may be a valuable agent for alleviating symptoms of</span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">A&beta;<span style="color:black">.</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><span dir="RTL" lang="FA" style="font-size:5.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><span dir="RTL" lang="FA" style="font-size:5.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span><br> &nbsp; بتاآمیلوئید, بیماری آلزایمر, سینامون, ماز آبی موریس  ​​​​​​​ Amyloid beta, Alzheimer's disease, Cinnamon, Morris water maze 53 61 http://ijpp.phypha.ir/browse.php?a_code=A-10-168-5&slc_lang=fa&sid=1 Zahra Azizi زهرا عزیزی 10031947532846007230 10031947532846007230 Yes Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran بخش فیزیولوژی و فارماکولوژی انستیتو پاستور ایران، تهران، ایران Samira Choopani سمیرا چوپانی 10031947532846007231 10031947532846007231 No Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran بخش فیزیولوژی و فارماکولوژی انستیتو پاستور ایران، تهران، ایران Nahid Majlessi ناهید مجلسی 10031947532846007232 10031947532846007232 No Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran بخش فیزیولوژی و فارماکولوژی انستیتو پاستور ایران، تهران، ایران