Iranian Journal of Physiology and Pharmacology
مجله فیزیولوژی و فارماکولوژی ایران
Ir J Physiol Pharmacol
Medical Sciences
http://ijpp.phypha.ir
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2022
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اثرات سینرژیستی نورومدین S با دوپامین و نورآدرنالین بر اخذ غذا در جوجه های 5 روزه
Synergistic effects of neuromedin S with dopamine and noradrenaline on food intake in 5-day-old chickens
غدد درون ریز
Endocrine
پژوهشي اصیل
Original Research
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">زمینه و هدف</span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">:</span></span><span lang="AR-SA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> دوپامین و نورآدرنالین نقش مهمی در کنترل اخذ غذا دارند. از طرفی </span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نورومدین </span></span><span dir="LTR" style="font-size:9.0pt">S</span> <span lang="AR-SA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">اخذ غذا را اکاهش می­دهد. مطالعه حاضر به منظور بررسی اثرات سینرژیستی دوپامین و نورآدرنالین با </span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نورومدین</span></span><span dir="LTR" style="font-size:9.0pt">S </span> <span lang="AR-SA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">بر اخذ غذا</span></span> <span lang="AR-SA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">در جوجه های پنج روزه صورت گرفت.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span lang="FA" style="font-family:"B Mitra"">روش کار:</span></b><span lang="FA" style="font-family:"B Mitra""> تعداد 132 جوجه 5 روزه بطور تصادفی در سه گروه آزمایشی تقسیم شدند. هر آزمایش شامل یک گروه کنترل و 3 گروه تیمار بود (11 جوجه در هر گروه). پرندگان پس از 3 ساعت محرومیت از غذا</span> <span dir="LTR" lang="FA" style="font-family:"B Mitra"">‎</span><span lang="FA" style="font-family:"B Mitra"">با تزریق داخل مغزی</span> <span lang="FA" style="font-family:"B Mitra"">بطنی‏</span> <span dir="LTR" lang="FA" style="font-family:"B Mitra"">‎</span><span lang="FA" style="font-family:"B Mitra"">محلول کنترل و ‏محلول دارویی را دریافت کردند. در آزمایش اول، محلول کنترل، </span><span lang="FA" style="font-family:"B Mitra"">نورومدین</span> <span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">S</span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""> (</span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">0/25 نانومول</span></span> <span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">، </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">ال- دوپا (125 نانومول)</span></span> <span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">و </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra"">نورومدین</span> <span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">S</span></span> <span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">+ </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">ال- دوپا </span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">تزریق شد.</span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""> در آزمایش دوم محلول کنترل، </span><span lang="FA" style="font-family:"B Mitra"">نورومدین</span> <span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">S </span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span style="font-family:"B Mitra"">(</span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">0/25 نانومول</span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">)، </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">دوپامین (<a name="_Hlk116552274">۱۰</a> نانومول) </span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">و </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra"">نورومدین</span> <span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">S</span></span> <span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">+ </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">دوپامین</span></span><span lang="FA" style="font-family:"B Mitra""> تزریق شد.‏ در آزمایش سوم محلول کنترل، </span><span lang="FA" style="font-family:"B Mitra"">نورومدین</span> <span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">S</span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""> (</span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">0/25 نانومول</span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">)، </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">نورآدرنالین 37/5 نانومول</span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""> و </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra"">نورومدین</span> <span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">S</span></span> <span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">+ </span></span></span></span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">نورآدرنالین </span></span><span class="fontstyle01" style="font-family:MyriadPro-Semibold,"serif""><span style="color:#1d1d1b"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra"">تزریق شد.</span></span></span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span lang="FA" style="font-family:"B Mitra"">یافته ­ها:</span></b><span lang="FA" style="font-family:"B Mitra""> با وجود اینکه تزریق نورومدین </span><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">S</span></span><span lang="FA" style="font-family:"B Mitra""> با </span><span lang="FA" style="font-family:"B Mitra"">دوز <span style="color:black">0/25 (دوز تحت اثر)</span></span><span lang="FA" style="font-family:"B Mitra"">، ال دوپا با دوز 125 (دوز تحت اثر)، دوپامین با دوز </span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">۱۰ (دوز تحت اثر)</span></span> <span lang="FA" style="font-family:"B Mitra""> و نورآدرنالین با دوز <span style="color:black">37/5 (دوز تحت اثر)</span></span> <span lang="FA" style="font-family:"B Mitra"">به صورت مجزا تاثیری بر اخذ غذا نداشت (0/05</span> <span lang="FA" style="font-family:"B Mitra""><</span><i><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">p </span></span></i><span lang="FA" style="font-family:"B Mitra"">)، تزریق نورومدین </span><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">S</span></span><span lang="FA" style="font-family:"B Mitra""> همراه با ال دوپا و یا دوپامین و یا</span><span lang="FA" style="font-family:"B Mitra""> نورآدرنالین موجب کاهش اخذ غذا شد (0/05 > </span><i><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif"">p</span></span></i><span lang="FA" style="font-family:"B Mitra"">).</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:99%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span lang="FA" style="line-height:99%"><span style="font-family:"B Mitra"">نتیجه گیری:</span></span></b><span lang="FA" style="line-height:99%"><span style="font-family:"B Mitra""> با توجه به نتایج، احتمالا یک اثر سینرژیستی بین </span></span><span lang="FA" style="line-height:99%"><span style="font-family:"B Mitra"">نورومدین</span></span> <span dir="LTR" style="font-size:9.0pt"><span style="line-height:99%"><span style="font-family:"Times New Roman","serif"">S</span></span></span><span style="line-height:99%"><span style="font-family:"B Mitra""> با دوپامین و نورآدرنالین در کنترل اخذ غذا وجود دارد.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:99%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><span lang="FA" style="font-size:5.0pt"><span style="line-height:99%"><span style="font-family:"B Mitra""><span style="color:black"></span></span></span></span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">Background and aims:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> Dopamine</span></span></span><span lang="EN-PH" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> and</span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">noradrenaline </span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">play an important role in food intake control. On the other hand, neuromedin S (NMS) decreases food intake. This study aimed to investigate the synergistic effects of dopamine</span></span></span><span lang="EN-PH" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> and</span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">noradrenaline </span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">with a sub-effective dose of NMS on food intake in neonatal chickens.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">Methods:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">A total of 132 five-old-day chicks</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> were randomly divided into three experimental groups. Each experiment had a control group and three treatment groups (n = 11 in each group). Three-hour food-deprived birds received intracerebroventricular </span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"B Mitra"">‎</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">injections of either control diluent or drug solution. In the first experiment, </span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">control solution, </span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">NMS (0.25 nmol), <span style="color:#131413">L-DOPA (dopamine precursor; 125 nmol</span></span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">)</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">, and NMS + <span style="color:#131413">L-DOPA</span> were injected.</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"B Mitra"">‎</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> In the second experiment, </span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">control solution,</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> NMS (0.25 nmol), <span style="color:black">dopamine</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">(10 nmol), and NMS + <span style="color:black">dopamine</span> were injected. In the </span></span></span><span lang="EN-PH" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">third</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> experiment, </span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">control solution,</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> NMS (0.25 nmol), noradrenaline</span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">(37.5 nmol), and </span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">,</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> NMS + noradrenaline were injected.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif"">Results:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""> Although the injection of NMS with a dose of 0.25 (sub-effective dose), L-dopa with a dose of 125<br>
(sub-effective dose), dopamine with a dose of 10 (sub-effective dose), and noradrenaline with a dose of 37.5 (sub-effective dose) had no effect on food intake (<i>p</i> < 0.05), the co-injection of Neuromedin S with L-dopa or dopamine or noradrenaline decreased food intake (<i>p</i> < 0.05).</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="font-family:Verdana,"sans-serif""><b><span style="font-family:"Times New Roman","serif"">Conclusion:</span></b> <span style="font-family:"Times New Roman","serif"">According to the results</span><span style="font-family:"Times New Roman","serif""> of the present study</span><span style="font-family:"Times New Roman","serif"">, there is probably a synergistic effect between </span><span style="font-family:"Times New Roman","serif"">NMS</span><span style="font-family:"Times New Roman","serif""><span style="color:black"> with </span></span><span style="font-family:"Times New Roman","serif"">dopamine</span><span lang="EN-PH" style="font-family:"Times New Roman","serif""><span style="color:black"> and</span></span> <span style="font-family:"Times New Roman","serif"">noradrenaline </span><span style="font-family:"Times New Roman","serif"">on food intake control of neonatal chicks.</span></span></span></span></span></span><span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:130%"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><span lang="FA" style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">‎</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
اخذ غذا, جوجه, دوپامین , نورآدرنالین, نورومدین S
Food Intake, Chicken, Dopamine, Noradrenaline, NMS
220
228
http://ijpp.phypha.ir/browse.php?a_code=A-10-115-22&slc_lang=fa&sid=1
Kourosh
Gholami Ahmadabadi
کوروش
غلامی احمدآبادی
10031947532846007146
10031947532846007146
No
Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
گروه علوم پایه، دانشکده دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
Morteza
Zendehdel
مرتضی
زنده دل
10031947532846007147
10031947532846007147
Yes
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
گروه علوم پایه، دانشکده دامپزشکی، دانشگاه تهران، تهران، ایران
Bita
Vazir
بیتا
وزیر
10031947532846007148
10031947532846007148
No
Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
گروه علوم پایه، دانشکده دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
Vahab
Babapour
وهاب
باباپور
10031947532846007149
10031947532846007149
No
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
گروه علوم پایه، دانشکده دامپزشکی، دانشگاه تهران، تهران، ایران
Ahmad
Asghari
احمد
اصغری
10031947532846007150
10031947532846007150
No
Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
گروه علوم درمانگاهی، دانشکده دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران