Iranian Journal of Physiology and Pharmacology
مجله فیزیولوژی و فارماکولوژی ایران
Ir J Physiol Pharmacol
Medical Sciences
http://ijpp.phypha.ir
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admin
2588-4042
2588-4050
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jalali
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2025
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تأثیر شش هفته تمرین تناوبی با شدت بالا (HIIT) بر سطوح سرمی فاکتور نوروتروفیک مشتق از مغز (BDNF)، افسردگی و شخصیت ضداجتماعی زنان در حال ترک اعتیاد
The effect of six weeks of high-intensity interval training (HIIT) on serum levels of brain-derived neurotrophic factor (BDNF), depression, and antisocial personality in women undergoing drug withdrawal
فیزیولوژی ورزش
Exercise physiology
پژوهشي اصیل
Original Research
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span lang="FA" style="background:white"><span style="font-family:"B Mitra""><span style="color:black">زمینه و هدف: </span></span></span></b><span lang="FA" style="font-family:"B Mitra""><span style="color:black">فاکتور نوروتروفیک مشتق از مغز یک نشانگر در اختلالات روانپزشکی است. مطالعه با هدف بررسی اثر شش هفته تمرین تناوبی با شدت بالا</span></span> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">بر سطوح فاکتور نوروتروفیک مشتق از مغز، افسردگی و شخصیت ضداجتماعی زنان در حال ترک اعتیاد انجام شد.</span></span><b><span lang="FA" style="background:white"><span style="font-family:"B Mitra""><span style="color:black"></span></span></span></b></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span lang="FA" style="background:white"><span style="font-family:"B Mitra""><span style="color:black">روشها<a name="_Hlk160478685">: </a></span></span></span></b><span lang="FA" style="font-family:"B Mitra""><span style="color:black">جامعه آماری در پژوهش نیمه</span></span><span dir="LTR" style="font-size:9.0pt"><span style="color:black"></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">تجربی حاضر، زنان در حال ترک اعتیاد به مواد مخدر سنتی، 35-30 سال در زاهدان بودند. 20 نفر از این زنان بهصورت هدفمند انتخاب و به طور تصادفی در دو گروه:</span></span> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">تمرین تناوبی با شدت بالا و کنترل قرار گرفتند. پروتکل تمرینی به مدت شش هفته، هر هفته سه جلسه و شامل: (گرم کردن 8 دقیقه و چهار ست چهار دقیقهای با شدت 85 تا 95 درصد حداکثر ضربان قلب؛ با استراحت 3 دقیقهای بین هر ست و در نهایت، استراحت 5 دقیقهای)، بود. از آزمون تیمستقل برای مقایسه بین گروهها و تیوابسته برای بررسی تفاوت درون گروهی با استفاده از </span></span><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""><span style="color:black">SPSS-26</span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black"> با سطح معناداری 0/05</span></span> <span lang="FA" style="font-size:9.0pt"><span style="background:white"><span style="font-family:"B Mitra""><span style="color:black">></span></span></span></span><i><span dir="LTR" style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Times New Roman","serif""><span style="color:black">p</span></span></span></span></i> <span lang="FA" style="font-family:"B Mitra""><span style="color:black"> استفاده گردید. </span></span><span lang="FA" style="background:white"><span style="font-family:"B Mitra""><span style="color:black"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span lang="FA" style="background:white"><span style="font-family:"B Mitra""><span style="color:black">یافتهها: </span></span></span></b><span lang="FA" style="font-family:"B Mitra""><span style="color:black">نتایج نشان داد که تفاوت معنی­داری در سطح </span></span><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""><span style="color:black">BDNF</span></span></span><span style="font-family:"B Mitra""><span style="color:black"> (0/01</span></span> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">=</span></span><i><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""><span style="color:black">p</span></span></span></i> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">) و افسردگی (0/00</span></span> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">=</span></span><i><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""><span style="color:black">p</span></span></span></i> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">) بین دو گروه در مرحله پسآزمون وجود دارد ولی در اختلال شخصیت ضداجتماعی و وزن بین دو گروه در این مرحله تفاوتی وجود نداشت (0/05</span></span> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">=</span></span><i><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""><span style="color:black">p</span></span></span></i> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">). اختلاف معنی­ داری بین پیشآزمون و پسآزمون در سطح </span></span><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""><span style="color:black">BDNF</span></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">، افسردگی، اختلال شخصیت ضداجتماعی و وزن آزمودنیها در هر</span></span> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">کدام از گروهها وجود داشت (0/00</span></span> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">=</span></span><i><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""><span style="color:black">p</span></span></span></i> <span lang="FA" style="font-family:"B Mitra""><span style="color:black">).</span></span><b><span dir="LTR" style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Times New Roman","serif""><span style="color:black"></span></span></span></span></b></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span lang="FA" style="background:white"><span style="font-family:"B Mitra""><span style="color:black">نتیجهگیری: </span></span></span></b><span lang="FA" style="font-family:"B Mitra""><span style="color:black">در مطالعه ما شش هفته تمرین تناوبی با شدت بالا منجر به افزایش سطح </span></span><span dir="LTR" style="font-size:9.0pt"><span style="font-family:"Times New Roman","serif""><span style="color:black">BDNF</span></span></span><span lang="FA" style="font-family:"Times New Roman","serif""><span style="color:black"> و </span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">کاهش افسردگی در زنان در حال ترک اعتیاد شد، اما بر ویژگیهای شخصیتی ضداجتماعی تاثیر معناداری نداشت. این نتایج میتواند اثر بالقوه تمرین تناوبی با شدت بالا را به</span></span><span dir="LTR" style="font-size:9.0pt"><span style="color:black"></span></span><span lang="FA" style="font-family:"B Mitra""><span style="color:black">عنوان مداخلهای برای بهبود نتایج سلامت روان در این جمعیت خاص برجسته نماید.</span></span></span></span></span></span></span><span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""> <span lang="FA" style="font-size:5.0pt"><span style="font-family:"B Mitra""><span style="color:black"></span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="line-height:130%"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">Background and Aim</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">: Brain-derived neurotrophic factor is a marker in psychiatric disorders. The study aimed to investigate the effect of six weeks of high-intensity interval training on brain-derived neurotrophic factor levels, depression, and antisocial personality in women undergoing drug withdrawal.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:130%"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">Methods:</span></span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">The statistical population in the present semi-experimental study was women in the process of quitting traditional drug addiction, aged 30-35, in Zahedan. 20 of these women were purposefully selected and randomly assigned to two groups: high-intensity interval training and control.</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">Six-week training protocol, three sessions per week,</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">and included: (8-minute warm-up and four four-minute sets at an intensity of 85 to 95% of maximum heart rate; with a 3-minute rest between each set and finally, a 5-minute rest). An independent t-test was used to compare between groups, and a dependent t-test was used to examine the difference within groups using SPSS-26 with a significance level of <i>p</i> < 0.05.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:130%"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">Results:</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black"> The results showed that there was a significant difference in BDNF levels (<i>p</i> = 0.01) and depression (<i>p</i> = 0.00) between the two groups at the post-test stage, but there was no difference in antisocial personality disorder and weight between the two groups at this stage (<i>p </i>= 0.05). There was a significant difference between the pre-test and post-test in BDNF levels, depression, antisocial personality disorder, and the weight of the subjects in each group (<i>p</i> = 0.00).</span></span></span></span><span dir="RTL" lang="FA" style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"B Mitra""><span style="color:black"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:130%"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">Conclusion</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">:</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:130%"><span style="font-family:"Times New Roman","serif""><span style="color:black">In our study, six weeks of high-intensity interval training increased BDNF levels and reduced depression in women undergoing drug withdrawal, but had no significant effect on antisocial personality traits. These results highlight the potential effectiveness of high-intensity interval training as an intervention to improve mental health outcomes in this specific population.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,"sans-serif""><span dir="RTL" lang="FA" style="font-family:"B Mitra""><span style="color:black"></span></span></span></span></span></span><br>
افسردگی, تمرین تناوبی با شدت بالا, زنان در حال ترک اعتیاد, شخصیت ضداجتماعی, فاکتور نوروتروفیک مشتق از مغز
Women recovering from addiction, Antisocial personality, BDNF, Depression, High-intensity interval training
74
83
http://ijpp.phypha.ir/browse.php?a_code=A-10-642-8&slc_lang=fa&sid=1
Forough
Dahmardeh
فروغ
دهمرده
10031947532846007067
10031947532846007067
No
Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran
دانشکده علوم تربیتی و روانشناسی، دانشگاه سیستان و بلوچستان، زاهدان، ایران
Majid
Vahidian-Rezazadeh
مجید
وحیدیانرضازاده
10031947532846007068
10031947532846007068
No
Department of Sport Sciences, Montazeri Technical College of Mashhad, Technical and Vocational University, Mashhad, Iran
دانشکده فنی شهید منتظری، دانشگاه فنی و حرفهای خراسان رضوی، مشهد، ایران
Omid
Mohammaddoost
امید
محمددوست
10031947532846007069
10031947532846007069
Yes
Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran
دانشکده علوم تربیتی و روانشناسی، دانشگاه سیستان و بلوچستان، زاهدان، ایران