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Effects of eight-week resistance training on serum level of βKlotho and FGF21 in diabetic women with non-alcoholic fatty liver disease
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Khadijeh Fereidoonfar   , Amirabbas Monazzami *  , Zohreh Razimi , Mehrali Rahimi |
| Department of Sport Physiology , Faculty of Sport Science, Razi University, Kermanshah, Iran |
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Abstract: (1518 Views) |
Background and aims: Research on the effects of resistance training on fibroblast growth factor 21 (FGF21) and βKlotho protein expression in patient with nonalcoholic fatty liver disease (NAFLD) is limited. We aimed to determine effects of eight weeks resistance training on serum level of βKlotho and FGF21 in diabetic women with NAFLD.
Methods: Thirty diabetic women (age 53 ± 7, height 158±4, weight 75 ± 9) with NAFLD participated in this study Subjects were randomly divided into two groups of control (n = 15) and exercise (n = 15). The training group performed resistance training of upper and lower body muscles in 3 sets of 50% - 70% of one repetition and 10-16 repeat in each session and three sessions per week for eight weeks. The control group did not perform any exercise program. Leg and chest muscle strength was measured by one repetition maximum (1RM) test. Serum level of βklotho and FGF21were measured by ELISA technique. Two-way ANOVA test with repeated measures with p < 0.05 was used to determine the significant differences.
Results: Except for βKlotho and insulin serum levels, none of the other variables of the control group showed significant difference in pre and post training. However, in the training group, weight, fat percent, body mass index, Waist to hip ratio, insulin, glucose, βKlotho and FGF21 levels were significantly changed after training (p < 0.05). A significant difference was observed between control and training groups in βKlotho and FGF21 levels (p < 0.05).
Conclusion: Resistance training could improve imbalance of FGF21 and βKlotho protein expression in women with type 2 diabetes and NAFLD. |
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| Keywords: Resistance training, type 2 Diabetes, non-alcoholic fatty liver disease, Insulin resistance |
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Full-Text [PDF 1199 kb]
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Type of Study: Original Research |
Subject:
Exercise physiology
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